Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model마우스 모델에서 SARS-CoV-2 공격에 대한 보호 반응 유도에 대한 최적화된 서열과 SARS-CoV-2의 스파이크 단백질 야생형 DNA 서열의 비교Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] acid Against Antiviral binding breath CD4 CD8+ cellular immune responses cellular immunity challenge clinical trial contributing to COVID-19 CTL demonstrated DNA DNA vaccine expression full-length spike protein hACE2 humoral humoral and cellular immunity IFN-γ immune immune responses immunogen in vitro induction mice Model mouse Neutralizing antibodies optimization optimizations pGX-9501 platform Protective Protective effects protective response RBD binding response robust SARS-CoV-2 sequence spike Spike protein subsequent T cell T cells the vaccine Transgenic mouse Type virus wild-type wild-type sequence. [DOI] 10.1080/21645515.2021.2016201 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Variant-Specific Infectivity and Immune Profiles Are Detectable in a Humanized Lung Mouse ModelArticle Published on 2022-10-162022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] animal model B.1.1.7 B.1.1.7 variant expected greater higher infectivity Human immune system human lung tissue humanized humanized mice immune cells Immune profile immune response Immunity Infection Infectivity lesion Lineage lung lung organoid mice Model mouse no difference overlapping Pathogenesis pathogenesis of SARS-CoV-2 profile replication of SARS-CoV-2 required Research SARS-CoV-2 SARS-COV-2 infection similarity Support supported sustained Th1 Th2 variant variants of concern variants of concern. Viral load viral variant Viral variants virus [DOI] 10.3390/v14102272 PMC 바로가기
The N501Y Mutation of SARS-CoV-2 Spike Protein Impairs Spindle Assembly in Mouse OocytesArticle Published on 2022-10-012022-11-16 Journal: Reproductive Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] accompanied assembly caused control group COVID-19 pandemic demonstrated female functions Health impairment indicated Infection influence maturation mouse mutant mutant spike protein N501Y N501Y variant Oocyte Oocyte maturation oocytes potential risk Protein provided reproductive SARS-CoV-2 SARS-CoV-2 spike protein significantly increased spike spike protein. Spindle spindle assembly the mean [DOI] 10.1007/s43032-021-00809-7 PMC 바로가기
Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cellsArticle Published on 2022-09-212022-11-15 Journal: eLife [Category] 바이오마커, 유전자 메커니즘, [키워드] alveolar alveolar epithelial cell alveolar epithelium alveolar regeneration Basal cell basal cells Biomarkers cause Cell Cell Biology Complete COVID-19 ectopic epithelial epithelial cell function IMPROVE increase independent Infection lineages lung lung parenchyma lung regeneration Lungs mechanism mice mouse mouse model Notch other organs proliferate promote promoted regenerative regenerative medicine regulate significantly stem cells suggested suppressed Tamoxifen tuft cell tuft cells viral infection Viral infection. Wnt [DOI] 10.7554/eLife.78217 PMC 바로가기
SARS-CoV-2 variant spike and accessory gene mutations alter pathogenesisArticle Published on 2022-09-132022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, [키워드] accessory gene Accessory genes accessory protein acute respiratory syndrome Affect Alter both virus cells characterized clinical disease clone contribute coronavirus COVID-19 pandemic Deletion driven by Effect ENhance evade Genome Host in vitro in vivo innate immune mouse Mutation pandemic Pathogenesis persists Protein public health crisis Receptor binding replaced Replication replication of SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 variant shown Signaling spike mutation Spread the spike protein Transmission Vaccine vaccine responses variant variant spike Variant. Viral variants virus virus viruses [DOI] 10.1073/pnas.2204717119 PMC 바로가기
Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and miceArticle Published on 2022-08-302022-11-15 Journal: Cell Reports [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome animal model antibodies Antibody Response approved BALB/c mice breadth coronavirus COVID-19 CP: Immunology CP: Microbiology elicited Human humans immune evasion mice mouse Neutralizing antibody response Neutralizing antibody titer non-human primate non-human primates public health real time SARS-CoV-2 SARS-CoV-2 variant sensitivity understanding vaccine platform Vaccines Vaccines. VOCs [DOI] 10.1016/j.celrep.2022.111299 PMC 바로가기
A SCID Mouse Model To Evaluate the Efficacy of Antivirals against SARS-CoV-2 InfectionSARS-CoV-2 감염에 대한 항바이러스제의 효능을 평가하기 위한 SCID 마우스 모델Article Published on 2022-08-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 치료제, [키워드] ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral drug antiviral drugs antiviral efficacy antivirals B.1.351 B.1.351 variant BALB/c Beta Beta variant binding C57BL/6 CAGE coronavirus Culture drug hamsters Infection infectious virus titer infectious virus titers Infective dose inhibitors intrinsic lack log lung Lung pathology Lungs male mice Model moderate molnupiravir mouse mouse model Mouse models Nirmatrelvir nirmatrelvir. offer Postinfection reagent receptor reduced replicate Replication reported SARS-CoV-2 SARS-CoV-2 mouse model SARS-CoV-2 strain SARS-CoV2 SCID significantly TCID These data tissue tissue culture twice a day Validity variant variants variants of concern Viral load virus virus strain wild-type [DOI] 10.1128/jvi.00758-22 PMC 바로가기 [Article Type] Article
Early Isolates of SARS-CoV-2 Result in Different Pathogenesis in the Transduced Mouse Model of COVID-19SARS-CoV-2의 초기 분리물은 COVID-19의 형질도입된 마우스 모델에서 다른 병인을 초래합니다Article Published on 2022-08-132022-09-11 Journal: Viruses [Category] SARS, 변종, [키워드] Adenovirus alveolar inflammation BALB/c mice body weight Body weight loss Clinical sign Clinical signs COVID-19 dissemination expression followed by hACE2 hACE2 receptor Histopathology in vivo Infection isolate isolates kidney liver lung Lung histopathology Lungs mice Model mouse mouse model peaking post infection provide response Result resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 virus variant spleen subsequent recovery susceptible the SARS-CoV-2 virus transduced transduction undetectable Victoria viral variant Viral variants virulence virulence. virus weight loss [DOI] 10.3390/v14081769 PMC 바로가기 [Article Type] Article
The Efficacy of Aprotinin Combinations with Selected Antiviral Drugs in Mouse Models of Influenza Pneumonia and Coronavirus Infection Caused by SARS-CoV-2SARS-CoV-2로 인한 인플루엔자 폐렴 및 코로나바이러스 감염의 마우스 모델에서 선택된 항바이러스제와 아프로티닌 조합의 효능Article Published on 2022-08-052022-09-11 Journal: Molecules [Category] SARS, 치료제, [키워드] Antiviral antiviral drugs Aprotinin body weight Body weight loss clinical assessment Combination combinations coronavirus COVID-19 demonstrated drug Efficacy Infection Influenza influenza pneumonia Influenza virus influenza. lung Lungs mice Model mouse preclinical study reducing SARS-CoV-2 selected survival rate treatment of influenza virus virus titer weight loss [DOI] 10.3390/molecules27154975 PMC 바로가기 [Article Type] Article
Induction of Cross-Reacting Antibodies Against the COVID-19 by BCG Vaccination in the Mouse Model마우스 모델에서 BCG 백신 접종에 의한 COVID-19에 대한 교차 반응 항체 유도Article Published on 2022-07-302022-09-11 Journal: Current microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Against antibodies antibody Antibody Response approach BCG BCG vaccination boost COVID-19 cross-reacting antibodies demonstrated explain help humoral immune response Immune escape immune responses Immunity induce induction investigated latent tuberculosis latent tuberculosis infection Model mouse mouse model non-specific potential tool potential tools rabies reducing reported SARS-CoV-2 SARS-CoV-2 spike spike tested the antibody response the SARS-CoV-2 Tuberculosis vaccination Vaccines variants [DOI] 10.1007/s00284-022-02971-w PMC 바로가기 [Article Type] Article